Vestnik of the Foundation for Fundamental Research, 2009, No.3(49)
/ Publications / Scientific Journals
Vestnik of the Foundation for Fundamental Research, 2009, No.3(49)
|
VESTNIK OF THE FOUNDATION FOR FUNDAMENTAL RESEARCH Published by RUE "Publishing House «Belaruskaya Navuka»", Minsk, Republic of Belarus |
Number 3(49), 2009
CONTENTS
SCIENTIFIC PUBLICATIONS
Sharko O. L., Kniazeva O. V.
Synthesis of 1-O-alkyl-2-[N-(2,4-dinitrophenyl)-b-aminopropionyl]-sn-glycero-3-phosphocholine - chromogenic analogue of platelet activating factor. pp. 5-10
Summary: Chromogenic substrate for platelet activating factor acetylhydrolase assay was synthesized starting from bovine heart phosphatidylcholine (PC). 1-O-alkyl bond of lysophosphatidylcholine (LPC), typical for platelet activating factor, was obtained as a result of one-pot hydrolysis-hydrogenation of PC plasmalogen. The sn-2 hydroxyl group of LPC was acylated with chromogenic N-(2,4-dinitrophenyl)-b-aminopropionic acid. Platelet activating factor acetylhylhydrolase activity in blood plasma was assayed using a new chromogenic substrate.
Bashilov À. V., Spirydovich E. V., Tsimafeyeva V. A.
Antioxidizing properties and phytochemical composition representatives of family Begoniaceae. pp. 5-15
Summary: It is investigated integrated antioxidizing activity and biochemical screening the content of biologically active substance (flavonols, antocyanes, catechins, ascorbic acid, hydrophilic pectin and protopectin) eight representatives of family Begoniaceae. Perspectivity of use of such parameter as integrated antioxidizing activity for screening vegetative raw material with the purpose of expansion of the nomenclature of medical herbs, that testifies to necessity of researches in the field of antioxidizing properties of medical herbs, phytopreparats and biologically active additives of a phytogenesis is shown.
Lishtvan I. I., Strigutsky V. P., Thariouk T. Y., Drebenkova I. V.
Influence of oil-soluble surfactants colloidal structures transformation on their compositions synergism. pp. 22-31
Summary: It is established that synergism of compositions on the basis of commodity oil-soluble inhibitor of corrosion AKOR-1 is caused by exchange interaction of the initial components p-electrons, leading to formation of colloidal structures with the raised ability to interaction with a metal surface. Use of spectral methods allows to predict synergism and to reduce thereby necessary volume of experiments by working out of new compositions.
Tatur Ì. Ì., Ostrovsky V. V.
Methodology of classifier's formal synthesis and analysis. pp. 32-41
Summary: Mathematical model of elementary classifier, which can be adapted to different applied problems of recognition, is proposed. Characteristic features of classification are formulated on the base of proposed model, and it results in 8 standard tasks. Numerical test bases could be generated for each task. The form of these bases is function values for either random or determined input information. The bases are used for development and testing of classifiers and their teaching algorithms. Procedure of setting the experiments above the classifiers is proposed. Also the problem of correct comparative estimation of classifiers is investigated. Authenticity (for the clear) and accuracy (for the illegible) of classifiers are used as the criterion of effectiveness.
Nechipurenko N. I., Veres A. I., Griboedova T. V., Pashkovskaya I. D., Tishina L. A., Matusevich L. I.
Some metabolic disfunction in patients with dyscirculatory encephalopathy under treatment of mexidol. pp. 42-49
Summary: The function status of vascular endothelium, using ultrasound by the reaction of the brachial artery to reactive hyperemia, levels of NO metabolism products and antioxidant enzyms, the concentration of circulation endothelium cells, plasma and erythrocytes Na+ and K+ ions levels and blood osmolarity were studied at patients suffering from dyscirculatory encephalopathy. The influence of complex therapy with mexidol on these indicators was estimated. The study established that the therapeutic correction with mexidol enabled one to improvement clinical state of patients and function of endotheliocytes, which was displayed by pozitive dynamic of endothelium-dependent vasodilation. It was shown the decreasing level of descvamation endotheliocytes, increasing NO production, erythrocytes K+ level and normalize superoxidedismutase and catalase activity.
Litvinovskaya R. P., Raiman M. E., Anikeev V. I., Khripach V. A.
28-Homobrassinosteroids modified with a fragment of indolylacetic acid. pp. 50-56
Summary: By the reaction of 3-indolylacetic acid anhydride with 28-homobrassinosteroids a number of indolylacetoxy derivatives of 28-homobrassinosteroids were obtained.
Gerlovskiy D. O., Antonchick G. N., Litvinko N. M., Ogeyko N. G, Petrusevich I. I. Lakhvich F. A.
Pancreatic phospholipase A2 activity under action of 2-(cys-,cys-octadecadienoyl)cyclohexane -1,3-dione. pp. 57-64
Summary: Pancreatic PLA2 activity under action of 2-(cys-,cys-octadecadienoyl)cyclohexane -1,3-dione (substance I) was studied. Substance I, as was shown, has been reversible inhibitor (IC50 » 4×10-4 M) of pancreatic PLA2 activity toward mixed micelles of phosphatidylcholine and bile acids salts under modeling of food utilization conditions. Initial rate of substrate hydrolysis in presence of substance I decrease in 1.3 times. Linolic radical of substance I, as was supposed, has made more contribution into this inhibition than cyclohexanic fragment: at model experiment reaction rate decreases in presence of linolic acid in 1.8 time and in presence of cyclohexane-1,3-dione - in 1.2 time. It was found, that full inhibition of enzyme activity by substance I under increasing of ionic power by NaCl (0 - 3,9 M) have not been observed. That is evidence for participation of electrostatic and hydrophobic interactions with active site of enzyme during summary inhibitor effect of substance I.
Mitsiuk V. I., Ryzhkovskiy V. M., Tkachenka T. M.
The manganese antimony with copper or zinc solid solutions with B8-type and their properties. pp. 65-77
Summary: The solid solutions of B8-type (space group P63/mmc) between the manganese antimony and the nonmagnetic transition metals - zinc and copper - have been obtained in the work. X-ray diffraction has determined the B8-phase existence regions: for Mn1.1-xZnxSb it is 0£x£0.1 and 0£x£0.1 for Mn1.1-xCuxSb. Temperature investigations of the magnetization have been performed and the Curie temperatures of solid solutions have been extracted. The character of the magnetic interactions has been specified. On the basis of magnetic and Mossbauer data the conclusion was made about the preferable occupation by Cu and Zn atoms of the trigonal-bipyramidal interstitials of B8 structure.
COMPETITIONS RESULTS
A list of scientific works published under BRFFR financial support in 2008. p. 78
A list of republican and international scientific conferences supported by BRFFR in 2008. pp. 79-81
INTERNATIONAL RELATIONS
Minutes of the 6th CNRS-NASB Joint Commission Meeting. pp. 82-83
Designed and maintained by Dr. Nikolai N. Kostyukovich. Last updated: November 21, 2009
Created with assistance of Natalia N. Polovinko
Copyright © 2009 The National Academy of Sciences of Belarus
Copyright © 2009 Vestnik of the Foundation for Fundamental Research
